ABSTRACT

concentrations of estrone and estradiol similar that obtained with orally administered estrogen 8,9. For this reason, oncologists do not want patients with breast cancer to use estrogen cream administered intravaginally. Initially, the absorption of estrogen from the vagina is low because of the decreased vascularity; however, with continued treatment both the vascularity of the vagina and estrogen absorption increase10. Various forms of estrogen that are used for the treatment of vaginal atrophy and atrophic vaginitis (Table 16).