ABSTRACT
Fatigue is a common symptom in multiple sclerosis (MS) and can profoundly disrupt the occupational and social functioning of patients.[1-5] Approximately 75-90% of people with MS report fatigue, and for many patients it is a daily concern.[1,2,6] A number of recent studies, which have advanced our understanding of MS fatigue, are summarized in this review.[7-14]
DEFINITION AND MEASUREMENT OF FATIGUE
A useful working definition developed by a consensus conference of MS researchers and clinicians states that fatigue is ‘a subjective lack of physical and/or mental energy that is perceived by the individual or caregiver to interfere with usual and desired activities’.[15] The consensus conference definition emphasizes the person’s subjective experience. Selfreport measures are widely used to assess fatigue and have the advantages of ease of administration, convenience in clinical settings, and a focus on the experiences and concerns of patients.
