ABSTRACT
Plasma levels of olanzapine are linearly related to daily dose but there is substantial variation1, with higher levels seen in women2. The threshold level for response has been suggested to be 9.3 µg/l (trough sample)3 and 23.2 µg/l (12-hour post-dose sample)2. Severe toxicity may be associated with levels above 100 µg/l and death seen at levels above 160 µg/l4. A target range for therapeutic use of 20-40 µg/l has been proposed5.
