ABSTRACT

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INTRODUCTION

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PROCESS

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BACKGROUND

sitivity and Allergic Contact Dermatitis Test Methods

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Example of the Dilemma of GP Tests

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Mechanisms: Con

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tact Hypersensitivity/Allergic Contact Dermatitis

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Elicitation Phase

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Traditional Conta

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TEST METHODS

ct Hypersensitivity Tests-Guinea Pig

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The Local Lymph

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Node Assay (LLNA)—Murine

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Endpoint Analysis erythema

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WKH WHVW FKHPLFDO LV LQGLYLGXDODQLPDOGD DO'HDQHWDO

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Prolif

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eration measured:

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RIWKH//1$LGHQWLÀ DQGLUULWDQWV7KHSD VXFK PDWHULDOV 7KH LPSURYHPHQWZLWKU WKHDFFHSWHG*307

Other Murine Sys

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LLNA-Ex Vivo

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Mouse Ear Swell

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tems

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ing Test (MEST)

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SU

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MMARY OF ACD/CH ANIMAL MODELS

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FUTURE

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REFERENCES