ABSTRACT
Interferences in ICP-MS are generally classified into three major groups-spectral-, matrix-, and physical-based interferences. Each of them has the potential to be problematic in its own right, but modern instrumentation and good software combined with optimized analytical methodologies have minimized their negative impact on trace element determinations by ICP-MS. Let us take a look at these interferences in greater detail and describe the different approaches used to compensate for them.
