ABSTRACT
The skin is a tissue that separates the internal living organism from the external environment. It has a complex structure and performs many physiological functions such as metabolism, synthesis, temperature regulation, and excretion. The outermost layer of this organ, the stratum corneum (SC), is considered to be the main barrier to the percutaneous absorption of exogenous materials. The skin barrier is important in the maintenance of water within the body and in protection of the body from the ingress of compounds, particularly important from an occupational viewpoint for workers in the cosmetic and agrochemical industries (1).
