ABSTRACT
The many reactions discussed in Chapter 5 and 6 influence the delivery of the intoxicant to which the organism has been exposed or of the bioactivated species to its site of action. Some reactions decrease the concentration of circulating free intoxicant by partition, binding or by modifying its chemistry to make it less toxic. Other reactions increase the concentration of intoxicant by their transport into particular cell types or toxicity is increased by metabolism to more active species. Sometimes one intoxicant is metabolised into another and the distribution of the damage is changed. Sometimes the bioactivated species is so reactive that all the damage occurs in the cell or organ where the metabolism takes place, but with more stable metabolites damage may occur in other organs.
