ABSTRACT
In the early 1970s, a decision was made to breed a primate species in the ICI laboratories, to be used in early toxicological work, and also as an alternative to
Table 18.5. The effect of clofibrate on the absolute and relative liver weight in Monkey 1 to 3
Mean liver weight Clofibrate dose (%)
Males Females
Control 0.5 1.0 2.0 Control 0.5 1.0 2.0
Monkey 1 N= 3 1 2 3 2 — 1 4
Absolute weight (g) 153.7 120.1 125.5 127.5 116.0 — 99.5 142.1**
% Body weight 2.52 2.63 1.96 2.00 2.25 — 1.80 2.70**
Monkey 2 N= 2 2 2 2 2 1 1 2
Absolute weight (g) 132.7 129.2 141.5 161.7 113.0 106.6 105.9 154.5
% Body weight 1.71 2.06 1.85 2.00 2.44 2.13 2.35 2.68
Monkey 3 N= 4 4 4 4
Absolute weight (g) 89.1 97.8 86.9 104.9
% Body weight 2.36 2.79 2.38 3.18
*(—) No surviving animals. **Statistically significant increase compared with control (Student ’s t-test, p<0.05).
