ABSTRACT
Excretion of [1, 6-14C] DEHA by the rat is rapid as most of the radioactivity (75%) is recovered 24 h later. The low amount of residual 14C in the carcass after 72 h (1.5%) suggests that DEHA is not retained in organs involved in DEHA distribution (liver, kidney, muscle and adipose tissue). These findings have been substantiated by several authors (Takahashi et al., 1981; CMA, 1985). After oral dosing, radioactivity is recovered in urine (45%), faeces (21%) and CO2 (8%), and varies according to the
dosing vehicle used (Bergman and Albanus, 1987). Apparently, the recovery of radioactivity is not dependent of the dose used in the range 0.25-2 g kg-1 day - 1 (CMA, 1985).
