ABSTRACT
The hypothalamic-pituitary-gonadal axis controls reproduction. In primates, neurons scattered throughout the hypothalamus synthesize a decapeptide, gonadotrophin-releasing hormone (GnRH, also referred to as luteinizing hormone releasing hormone, LHRH) from a large precursor. GnRH is secreted from axon terminals in the median eminence into the portal system. GnRH stimulates gonadotrophs of the anterior pituitary to secrete two gonadotrophins, follicle stimulating hormone (FSH) and luteinizing hormone (LH).
