ABSTRACT

The genetic code is a triplet code During translation, the sequence of an mRNA molecule is read from its 5¢ end by ribosomes, which then synthesize an appropriate polypeptide. Both in prokaryotes and in eukaryotes, the DNA sequence of a single gene is colinear with the amino acid sequence of the polypeptide it encodes. In other words, the nucleotide sequence of the coding DNA strand, 5¢ to 3¢, specifies in exactly the same order the amino acid sequence of the encoded polypeptide, N-terminal to C-terminal.