ABSTRACT

The pathway Glucose is phosphorylated to glucose 6-phosphate (by hexokinase), which is converted to fructose 6-phosphate (by phosphoglucose isomerase) and then to fructose 1,6-bisphosphate (by phosphofructokinase, PFK). The fructose 1,6-bisphosphate is split into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (by aldolase) and these two trioses are interconverted by triose phosphate isomerase. Glyceraldehyde 3-phosphate is converted to 1,3-bisphosphoglycerate (by glyceraldehyde 3-phosphate dehydrogenase), which reacts with ADP to give 3-phosphoglycerate and ATP (catalyzed by phosphoglycerate kinase). The 3-phosphoglycerate is converted to 2-phosphoglycerate (by phosphoglycerate mutase) and then to phosphoenolpyruvate (PEP) by enolase. Finally, PEP and ADP react to form pyruvate and ATP (catalyzed by pyruvate kinase).