ABSTRACT
Cognitive function often is impaired in multiple sclerosis (MS) patients1. Prevalence estimates derived from two large controlled cross-sectional studies2,3
are remarkably similar. Once impairment rates in demographically matched healthy controls are taken into account, nearly half of all MS patients exhibit deficits on neuropsychological (NP) testing. The functional consequences of MS-related cognitive impairment can be devastating. Cognitive impairment has a direct impact on the ability to maintain employment4-6, driving skills and safety7,8, involvement in social activities4, personal and community independence4,6,9,10 and the likelihood of benefiting from in-patient rehabilitation11. Not surprisingly, it is a major source of care-giver strain12,13.
