ABSTRACT

This chapter is devoted to the use of “genome-wide” approaches to identify Yersinia virulence genes, with an emphasis on those technologies that can be directly applied during host infection. A number of these in vivo technologies are available. However, it is not the purpose of this chapter to go into the technical details of each available technique. For a comprehensive review of the available in vivo strategies, I refer the reader elsewhere (Handfield and Levesque, 1999).