ABSTRACT

Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials. Accessible to statisticians in clinical trials as well as oncologists interested in clinical trial methodology, the book presents up-to-date statistical approaches to the design and analysis of oncology clinical trials. New topics in this edition include trial designs for targeted agents, Bayesian trial design, and the inclusion of high-dimensional data and imaging techniques. This edition also contains numerous figures and examples to better explain concepts.

part II|76 pages

Phase II Trials

part III|230 pages

Phase III Trials

chapter 15|17 pages

Early Stopping of Clinical Trials

chapter 18|27 pages

Adaptive Trial Designs

part IV|205 pages

Exploratory and High-Dimensional Data Analyses

chapter 29|25 pages

Risk Calculators

chapter 32|13 pages

Methods for SNP Regression Analysis in Clinical Studies

Selection, Shrinkage, and Logic