ABSTRACT

Heavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson’s and Alzheimer’s diseases, cardiovascular disorders, and several others.

Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting.

Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals.

Key Features

  • Discusses the pathology of metal toxicity
  • Highlights the benefits of metals
  • Explains the mechanism and salient features of restoring metabolic homeostasis
  • Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity

The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals.

The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.

part II|41 pages

Pathology of Metal Toxicity

part IV|12 pages

Radionuclides Toxicity

part V|86 pages

Benefits of Metals

chapter Chapter 10|14 pages

Trivalent Chromium

A Vital Insulin Sensitizer

chapter Chapter 11|8 pages

Differential Impact of Organic Vanadium Compounds on Human Health

Deficiency States, Toxic Effects, and Potential Therapeutic Use

part VI|281 pages

Toxic Manifestations by Diverse Heavy Metals and Metalloids

chapter Chapter 13|19 pages

Clinical Toxicology of Copper

Source, Toxidrome, Mechanism of Toxicity, and Management

chapter Chapter 14|54 pages

Cadmium Exposure and Toxicity

chapter Chapter 15|13 pages

Cobalt Toxicity and Human Health

chapter Chapter 16|15 pages

Cobalt Toxicity

chapter Chapter 17|7 pages

Iron-Siderophore and Tumorigenesis

Molecular Insight and Therapeutic Targets 1

chapter Chapter 18|11 pages

Clinical Toxicology of Iron

Source, Toxidrome, Mechanism of Toxicity, and Management

chapter Chapter 19|21 pages

Vanadium Toxicity Revisited

Striking the Right Balance between Potential New Generation Therapeutics and Adverse Side Effects

chapter Chapter 21|20 pages

Lead Toxicity

An Overview of Its Pathophysiology and Intervention Strategies

chapter Chapter 22|19 pages

Arsenic Toxicity

Source, Mechanism, Global Health Complication, and Possible Way to Defeat

chapter Chapter 23|12 pages

Clinical Toxicology of Mercury

Source, Toxidrome, Mechanism of Toxicity and Management

chapter Chapter 24|12 pages

An Overview of Tungsten Toxicity

chapter Chapter 25|16 pages

Boron Toxicity

An Insight on Its Influence on Wheat Growth

chapter Chapter 27|10 pages

Lithium

Is It Good or Bad for Plant Growth?

chapter Chapter 28|10 pages

An Overview of Nickel Toxicity in Plants

chapter |3 pages

Commentary

A Treatise on Metal Toxicology