N Population Genetics and Evolutionary Studies
The theory first appeared in 1968 in a paper by K i m u r a which was soon fol lowed by the same idea written by K i n g and Jukes (1969) under the provocative title " N o n - D a r w i n i a n e v o l u t i o n " . The theory was immediately crit icized by several evolutionists o n the grounds that any mutat ional change can hardly be so nearly neutral as to be uninfluenced by select ion over long evolutionary periods, when extremely weak selective forces have time to act. In the years after 1968, the theory was debated at great length and sometimes w i t h bitter fervor. The arguments became increasingly quantitative and experimental , yet the answer to the controversy has remained elusive.