ABSTRACT
This chapter explores recent evidence relating to the quality, validity, and value of preclinical animal research (i.e., animal research that is expected to have relevance for humans), in the hope that it will provide a firm grounding for an updated ethics of animal research. The discussion is limited to the use of research animals as “models” of human conditions, where animals are used as proxies for humans in the hope that the understanding of biological phenomena gained in animals will be generalizable to humans.
