ABSTRACT
Data on long-term stability of reconstituted inotropic drugs at ambient temperatures are lacking. This study the assayed compatibility of four common inotropes after reconstitution under conditions usually practiced in the clinical area. Each inotropic solution (dopamine, dobutamine, epinephrine and norepinephrine) was prepared in triplicate by adding D5 W to a syringe to a final concentration of 1.4 mg/mL for dobutamine and dopamine, and 30 μg/mL for epinephrine and norepinephrine were achieved. The solutions were stored at temperature ranged 26–28°C under either mixed daylight or fluorescent. The sample was taken at 0, 8, 24, 72, 120, and 168 hours. The pH of solutions is stable. The concentrations of dobutamine, dopamine, epinephrine, and norepinephrine at 168 hours, compared to freshly prepared solution, were retained 91%, 105%, 90%, and 90%, respectively. Solutions of dobutamine, dopamine, epinephrine, and norepinephrine in D5W are compatible in prefilled syringes for up to 7 days.
