ABSTRACT
Ipomoea reptans Poir has become one of the traditional medicines for treating diabetes mellitus. In this study, we aimed to assess the effect of LD50 of ethanolic leaf extract from I. reptans in rats. Wistar rats (n = 70) were divided into five groups and orally treated with different doses. Each group contained seven male rats and seven female rats. Of these five groups, one was the control group and four were respectively given the leaf extract at doses of 600, 1500, 3750, and 9375 mg/kg. Toxicities were measured for 24 h and 2 weeks after administration. Mortality rates of rats were recorded after 24 h. The results of the acute toxicity test indicated that the quasi-LD50 of the leaf extract from I. reptans was more than 9375 mg/kg via oral route, and did not cause any toxic symptoms in rats.
