ABSTRACT
Variants of the Multidrug Resistance-1 (MDR1) gene play an important role in chemo-resistance in Acute Lymphoblastic Leukemia (ALL). In this study, we aimed to identify MDR1 gene variants 3435 and 2677 in children with ALL in Sanglah Hospital, Bali, and to determine their chemo-therapeutic outcome. All children with ALL admitted in Sanglah Hospital during May 2015 to January 2016 were included. The PCR method was used to identify the MDR1 gene. Remission status was determined after the induction phase of Indonesian Protocol ALL 2006. The sequencing results from 17 patients indicated that four children had mutations 3435T and 2677T, two possessed mutation 3435T and wild-type 2677G, and the remaining had wild-type 3435C and 26TTG. Of those 17 children, 16 were able to continue with the same chemotherapy protocol and had complete remission.
