ABSTRACT
The concomitant use of sodium diclofenac may inhibit the CYP2C9 metabolic pathway of glibenclamide, resulting in increased plasma glibenclamide levels and risk of hypoglycemia. However, the effect of drug-drug interaction between glibenclamide and sodium diclofenac on glycemic control is still unknown. This study aimed to evaluate the glycemic control of glibenclamide in the presence of sodium diclofenac. Male Wistar rats with Streptozotocin-induced diabetes were divided into three groups of treatments: glibenclamide alone, concurrent glibenclamide and sodium diclofenac, and 1-hour interval between glibenclamide and sodium diclofenac. Glibenclamide (0.45 mg/kg) or sodium diclofenac (4.5 mg/kg) were administered orally. Blood glucose levels were measured before drug administration (baseline) after 1, 2, 4 and 6 hours. No significant differences were observed between groups regarding glycemic control of glibenclamide in the absence or presence of sodium diclofenac (P > 0.05). Therefore, sodium diclofenac did not affect the glycemic control of glibenclamide.
