ABSTRACT
Congenital hyperinsulinism (HI) is the most common cause of persistent, long-term hypoglycaemia in newborns and infants.
● Definition – Congenital HI is a heterogeneous genetic disorder of the insulin metabolism that results in severe persistent neonatal hypoglycaemia. There are two major forms of HI: focal (in which only a discrete area of the pancreas is affected) and diffuse (in which the entire organ is diseased).
