Introduction

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book seeks to address a trio of objectives that, though separate, are linked and central to biomedical science and, ultimately, medicine. It presents how to deliver more of a drug product systemically to facilitate the regulatory need for evaluating safety and efficacy in animal species prior to advancing the drug to human testing, with the goal of translating the same lessons into humans and optimizing clinical use. The book explores ways to improve therapeutic target receptor delivery performance, therefore improving both clinical pharmacodynamics bioavailability and specificity. It considers concepts central to current pharmacotherapy and toxicodynamics – and how regulatory concepts and guidances hinder development but also could help improve the efficiency and success rate of development. The book seeks to understand the assumptions and concepts of pharmacokinetics.