ABSTRACT
Oral sustained drug delivery system (OSDDS) was subsequently developed as a promising alternative drug delivery system due to several advantages offered, including improved bioavailability, higher patient compliance, and reduced adverse effects and toxicity. However, drug absorption form gastrointestinal tract (GIT) can still be variable and unsatisfactory among different individuals, which ultimately compromises overall efficiency of OSDDS. Several gastroretentive drug delivery systems (GRDDS) have been developed in last two decades to prolong gastric retention time (GRT); the main aim being focused on improving performance of OSDDS along with optimizing therapy so as to attain significant patient compliance. Variability in performance of OSDDS in maximum circumstances is precipitated by unpredictable GRT, which does not allow OSDDS to stay at the absorption site until complete release of its drug content; with the process reported as premature gastric emptying of OSDDS.
