ABSTRACT
This chapter focuses on electrical stimulation (ES) promoting wound healing through fibroblast modulations. It explains how ES modulates fibroblast behaviors and functions during wound healing. Fibroblasts are a key player in epithelium restoration after injury. In a normal wound healing process, fibroblasts directly or indirectly, through mediators, play key roles in inflammation, the formation of granulation tissue, tissue reepithelialization, and remodeling. It is well established that keratinocytes and fibroblasts communicate with each other via double-paracrine signaling loops, known as cross talk or dynamic reciprocity, which coordinate their actions to maintain and, if needed, restore normal tissue homeostasis after wounding. Multiple strategies have been used to promote wound healing, including vacuum-assisted wound closure. Cell adhesion is essential in all aspects of development. As a key primary process, cell adhesion is tightly linked to different signaling pathways that are also involved in cell division, cell migration, cell differentiation, and apoptosis.
