ABSTRACT
Tumors of soft tissues consist of the following categories: adipocytic tumors, fibroblastic or myofibroblastic tumors, so-called fibrohistiocytic tumors, smooth muscle tumors, pericytic or perivascular tumors, skeletal muscle tumors, vascular tumors, chondro-osseous tumors, gastrointestinal stromal tumors, nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated or unclassified sarcomas. As a rare malignant mesenchymal tumor, angiosarcoma (synonyms: lymphangiosarcoma, hemangiosarcoma, hemangioblastoma, malignant hemangioendothelioma, and malignant angioendothelioma) typically shows anastomosing vascular channels lined by atypical and proliferative active endothelial cells, or solid sheets of high-grade epithelioid or spindled cells without clear vasoformation. Microscopically, angiosarcoma in soft tissue shows epithelioid and spindled areas. Epithelioid areas contain large rounded cells arranged in sheets, small nests, cords, or rudimentary vascular channels. These vascular channels intercommunicate sinusoidally and infiltrate surrounding tissues destructively, offering a useful diagnostic mark for angiosarcoma. Treatment options for soft tissue angiosarcoma include surgery, chemotherapy, and/or radiotherapy. Localized angiosarcoma is cured by aggressive surgery.
