V

Vaccination in America Boston physician, Zabdiel Boylston (1680–1766), inoculated his son in 1721 with the material taken from the pustule of a person with smallpox. Benjamin Colman (1673–1747) of Boston wrote a book on smallpox vaccination in the same year. Other American treatises include those of Coleman (1722), Increase Mather (1721), Benjamin Franklin (1706–1790) in 1759 and Benjamin Rush (1745–1813) in 1781. Benjamin Waterhouse (1754–1846), professor of medicine at Harvard, inoculated his four children in 1800 with a smallpox obtained from a physician named Haygarth of Bath, England. The Vaccine Institute was established at Baltimore by James Smith in 1802.