ABSTRACT
An amperometric sensor capable of detecting glucose without the addition of exogeneous reagents has application in the hospital, laboratory, and home health care markets. There has been significant recent activity in the development of glucose oxidase (GOD) based electrodes for use in amperometric glucose sensors which can be used in various media, including whole blood. By coupling the redox activity of GOD directly to an electrode surface it is possible in principle to develop an electrode which responds to glucose concentration without interference from O2 [1–4]. This approach requires the use of a low molecular weight mediator to act as an electron shuttle between GOD and the electrode surface. Ferrocene and its derivatives have been used as mediators for GOD [1,5,6].
