ABSTRACT
Molecular recognition in biological systems consists of complicated processes that generally involve initial formation of highly structured complexes between macromolecular hosts and their specific guests, followed by expression of biologically significant functions such as discrimination of antigens by antibodies, chemical transformation of substrates by enzymes, translocation of metal ions by carriers, and transduction of signals by receptors. These biological molecular recognition processes are quite often displayed at membrane surfaces rather than in homogeneous solutions. Especially, signal transduction at membrane surface resulting in “transmembrane signalling” (Figure 1) is one of the most interesting biological processes in view of the development of novel sensing systems. The transmembrane signalling frequently involves transduction of a chemical signal to an electric signal at membrane surface, the general transduction mode being membrane potential change and permeation ion current [1]. Molecular recognition at membrane surface involving host-guest complexation followed by signal transduction, resulting in “transmembrane signalling“. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315138404/dcbf45e3-36a3-4a59-956b-120bfad39a0a/content/fig6_1.tif"/>
