ABSTRACT
This chapter addresses the factors noted and reviews criteria for selection of cleaning strategies appropriate for the equipment to be cleaned and the residues to be removed. The selection of appropriate cleaning agents is critical to the success of the application of automatic cleaning methods. Several general mechanisms, or processes, of residue removal are commonly employed in the automatic cleaning of biopharmaceutical processing equipment. The practical application of the cleaning processes described involves the selection of cleaning agents that provide the means for the residue removal mechanisms appropriate to a specific process or residue. Automated cleaning systems are used widely for the cleaning of biopharmaceutical processing equipment and piping systems, with the goal being that of the reduction of post production and detergent residues to acceptable levels. Peptizing is an important mechanism in the removal of biopharmaceutical residues as proteins are nearly always present in the process, and they often comprise the final product.
