ABSTRACT
Recently, we reported that the MB is significantly compromised in response to DPCI and NPs used in theranostic applications (Sharma et al. 2013a; Sharma et al. 2013b). CMB triggers CB formation in the most vulnerable cell, involved in apoptosis, NDDs, and CVDs. MTs inhibit CB formation by acting as potent free radical scavengers, charnolophagy enhancers, and CS stabilizers. We proposed basically three types of NPs, including: toxic, neutral, and protective. Toxic NPs induce CB formation, neutral NPs have no effect on the MB, whereas, protective NPs inhibit CB formation and provide neuroprotection as well as cardiovascular protection (Sharma et al. 2013a).
