ABSTRACT
So far, we have considered generalized linear mixed-effects models and their related models for parallel group randomized controlled trials for comparing two treatment groups. In this chapter, we shall present some generalized linear mixed-effects models for other trial designs such as
• trials for comparing multiple treatments, • three-arm non-inferiority trials including a placebo, and • cluster randomized trials
within the framework of the S:T repeated measures design by taking for example Model V, a random intercept plus slope model for the average treatment effects. Unfortunately, however, I do not know of any real data on the above trials adopting the S:T design with S > 1 that is available. So, in this chapter, I shall mainly introduce generalized linear mixed-effects models with the S:T repeated measures design for each of the trial designs.
