This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage arm pain — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 60 years old woman who has a history of hypertension and depression. She is complaining of left-arm pain that has been present for a few weeks. She tells the general practitioner (GP) that it is a burning type of pain that involves the whole arm from her shoulder to her wrist. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.