This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to handle the confused patient — a case which they are likely to encounter in the future in a general practice setting. It also provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan. The chapter presents the case of an 87 years old woman who appeared dishevelled, agitated and confused in her room. On examination, in particular of the cardiovascular and neurological systems no abnormality is found. She is unable to answer the Folstein's Mini-Mental State Examination as she is confused, bewildered and disorientated in time, place and person. There is no sign of any injury.