This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage fever — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a wife who sought telephone advice on how best to manage her husband, 45-year-old man, who was suffering from fever for 2–3 days with aches and pains and also sweating and shivering. He also has a slight rash on his hands. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.