This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage acne — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a young man aged 15 years who has had mild acne for 2–3 years, but recently he has noticed more spots on his face and a few spots on his shoulders. And, he is worried that his acne is there because he does not wash enough or because he eats fatty food and likes chocolate. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.