This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage pain — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 62 years old woman who has come to see general practitioner with pain in epigastrium, right loin and sternum. She has already been diagnosed with anxiety, depression, hypochondriasis, mild personality disorder, globus hystericus, as well as type I diabetes, chronic bronchitis and recurrent urinary infections. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.