This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage penile rash — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 29-year-old builder with a week-long history of sores on his penis. The sores developed after sexual intercourse with his ex-wife when his foreskin ripped and bled. The patient also reports irritation in the urethra on and after micturition. He has not noticed any penile discharge. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.