This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage anaemia — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 25-year-old woman who was suffering anaemia during her pregnancy time. Remembering her own pregnancy, the practice nurse had taken blood for a full blood count. The results returned showing a microcytic, hypochromic anaemia. The nurse practitioner had prescribed a course of ferrous sulphate tablets at 200 mg three times daily for 4 weeks. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.