This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage skin depigmentation — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a mother who sought advice on how best to manage her 18-month-old infant who has depigmentation on his chest and abdomen. The mother is worried about psoriasis as the child's father suffers from this condition. There is no other family history of skin disease and the infant is otherwise healthy. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.