This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage skin rash — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a mother who sought advice on how best to manage her 5-year-old twins who have skin rash. One boy had the spots first, developing spots on his arms, then his legs and finally on his trunk. The other boy has developed a lesser number of spots, mainly affecting his arms. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.