This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage skin rash — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a mother who sought advice on how best to manage her 6-year-old boy who has an acute generalized rash. The rash is slightly itchy. On examination, the boy is well and apyrexial. He has a generalized rash covering his trunk and, to a lesser degree, his limbs. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.