This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage tremor — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 68-year-old man who was suffering from tremor. For the past few months, the man has noticed that his left hand has been shaking. The patient has been generally well, although he has developed benign prostatic hypertrophy which is being followed by the urologists. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.