This chapter, written for undergraduate medical students and post-graduate doctors in training, presents information on how to manage vaginal bleeding — a case which they are likely to encounter in the future in a general practice setting. It presents the case of a 21 years young woman who has recently had a miscarriage at 8 weeks gestation. The pregnancy was not planned but she and her boyfriend were very excited when they knew that she was pregnant and are now very upset about the loss. The chapter provides details of the patients' medical history and the key findings of clinical examination, together with initial investigation results data for evaluation, and helps them develop their skills of clinical reasoning. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible treatment plan.