ABSTRACT
Aging is an inevitable part of life for human and is associated with a decline in the physical and functional capacity of tissues and organs. Mild cognitive impairment and dementia, including Alzheimer's disease (AD), in particular, has emerged as a major debilitating illness associated with old age. The senescence-accelerated mouse (SAM) model was established from the AKR/J strain as a spontaneous murine model of accelerated senescence. Several studies have indicated that long-term administration of dietary bioactive components prevents learning and memory impairment in SAMP8 mice. A variety of fermented soybean products are widely consumed in Asian countries. AD is the most common form of dementia worldwide and represents a neurodegenerative disease characterized by a decline in cognitive and memory functions severe enough to interfere with normal activities of daily living. Some nuclear receptors play a beneficial role in reducing the risk of AD onset.
