ABSTRACT
This chapter begins with an introduction on basic data structure of chromatograms and common artifacts in chromatograms. It describes denoising, signal enhancement, and baseline correction methods for individual chromatogram. The chapter focuses on chemometric methods for solving problems when handling chromatographic datasets, and they will be elucidated as clearly as possible, from the simplest methods to the more sophisticated ones. It explains denoising of signals, signal enhancement, and baseline correction in chromatographic science. A chromatogram is a representation of the separation that has occurred in the chromatographic system, which is the most commonly used representation of chromatographic dataset. Baseline drift is a steady increasing or decreasing curve independent to the sample, which occurs because of disequilibrium of column, contamination of the system, stationary phase damage, and so on. Chromatography with various detectors offers a powerful tool for separating complex compounds to create characteristic chromatograms.
