ABSTRACT
Complexation is a phenomenon that binds closely one or more molecules of two compounds—a ligand and a substrate by noncovalent attractive forces of interaction. This chapter describes the types of molecular forces involved in the formation of coordination and molecular complexes. It also describes the influence of plasma–protein binding on the plasma concentration and biodistribution of drugs. The chapter explains the influence of plasma–protein binding on the plasma concentration and biodistribution of drugs. It also explains the factors affecting complexation and protein binding of drugs. The extent of protein binding of many drugs is a linear function of their oil–water partition coefficient, which is a measure of their hydrophobicity. This phenomenon can be used to predict the biological activity of a drug's analogs. Nonlinear regression is a computationally intensive parameter-estimation method that uses algorithms for adjusting the equation parameters to best fit the data.
