ABSTRACT
Erythema dyschromicum perstans (EDP) is a rare, chronic, benign skin disorder belonging to the group of idiopathic acquired hypermelanoses. EDP tends to affect darker-skinned individuals, particularly those of Hispanic decent, but cases with Caucasian, Indian, and African American patients have also been described. The underlying pathophysiology of EDP, as well as its exact etiology, remains obscure. Impairment of the immune system may play a role in the pathogenesis of EDP. EDP is a pigmentary disorder with insidious onset and slow progression. The clinical course may differ between adults and children patients. In the early stages of the disease, the macules may be surrounded by erythematous, elevated, nondesquamative borders measuring 1-2 mm in width, which eventually fade after months. The histological pattern differs between the early and late phases of the eruption. Treatment of EDP is challenging. Suggested treatments include dapsone, clofazimine, topical tacrolimus, and ultraviolet phototherapy.
