ABSTRACT
Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disorder of the Central Nervous System (CNS) characterized with inflammation and demyelination. People who suffer with MS undergo several disease processes, including periphery inflammation, blood-brain barrier damage, demyelination and CNS lesions. Accumulation of auto-reactive T cells and microglia/macrophages under MS condition has been reported to be correlated with axonal loss. MicroRNAs (miRNAs) are short non-coding RNA of length ranging from 19 to 25 bases and are involved in post transcriptional gene regulation. Association of miRNAs with MS disease severity revealed them as biomarkers for monitoring MS progression. Thus, in order to unblock bottlenecks in MS treatment strategies, study of specific miRNA-regulated checkpoints that control myelinogenesis/demyelation with diagnostic and/or therapeutic application in CNS myelin repair is needed.
